Job Posting Details

Flow Cytometry Specialist

Posted By: John Cheng

Post Date: February 13, 2010
Affiliation: Pfizer Global Research and Development
Expiration Date: May 31, 2010

Job Title: Biomarker Principal Scientist - Flow Cytometry

Laboratory, Pfizer Global R&D – Groton Laboratory

Location: Groton, Connecticut

Contact: Dr. John B. Cheng, e-mail:, Tel: (860) 441-3351

Role Description

Responsible for independent

initiation and execution of scientific research and/or development strategies

in a biomarker focused flow cytometry laboratory. This senior level scientist

will act as technical scientific expert regarding cellular markers using FACS

and cell imaging technologies to regulated preclinical biomarker and clinical

biomarker translation supporting Pfizer drug candidates. Responsible for

providing flow cytometry data for biomarker discovery and development, support

assay method development and standardization, and contribute toward staff

training and professional development.  Candidate will participate with

departmental teams and research units in a matrix environment. The person

should have proven experience in the delivery of flow and cell imaging-based

biomarkers in animal and clinical studies, and have strong knowledge of

biological systems and cellular function to enable Pfizer discovery and

development objectives.


- The successful candidate will

have experience developing partnerships in a matrix environment, influencing

project strategies, and leadership in technology development and


- Candidate must have experience training and

developing FACS scientists in a team environment. Other responsibilities include

independent planning of laboratory activities, understanding and influencing

therapeutic area biomarker strategies to use biomarkers in scientific


- Candidate will participate in all phases of FACS

laboratory operations including technology evaluations, the development of

sample preparation, separation and detection methods, data analysis,

interpretation, reporting and follow up discussions with the project teams on

utilizing the data in appropriate decision making.

- Proactively gathers input from colleagues, teams

& management to avoid/address issues at functional level and participates

on cross discipline matrix teams

- Excellent oral/written communication skills

- Demonstrated ability to clearly & concisely

communicate bioanalytical information (including Q&A)

- Understanding of “fit-for-purpose” assay

development and support.  Ability to effectively balance assay rigor

against resource needs and study goals

- Knowledge and understanding of GLP/GCP guidance for

execution of preclinical and clinical studies supporting NCE’s


B.S. (>8 years), M.S. (>6 years), or Ph.D. (>2-4 years) in relevant scientific field with industrial

experience; Experience in development, characterization, and implementation of

quantitative bioanalytical assays (e.g., flow cytometry and cell imaging) using

wet sample preparation methods and instrumentation

Additional qualifications include:

- Experience and knowledge in operation of modern

flow cytometry and cell sorting platforms and associated data/LIMS systems

- Knowledge and application of immunoassay techniques

as applied to flow cytometry techniques

- Knowledge and application of sample preparation

methodologies as applied to flow cytometry techniques

- Good understanding of biochemistry and cellular


- Ability to lead teams, coach and mentor colleagues

and influence in a matrixed environment

- Knowledge and understanding of GLP and GCP

regulations and guidelines

- Good written and oral communication skills

- Ability to act decisively in a matrix environment

- Rapidly seizes accountability and takes independent


- Ability to deal with project and organizational

change while supporting the organization

- Interested in personal development and professional


- Aware of  self and others