Job Posting Details

Flow Cytometry Specialist

Posted By: John Cheng

Post Date: February 13, 2010
Affiliation: Pfizer Global Research and Development
Expiration Date: May 31, 2010
Department:
Description:









Job Title: Biomarker Principal Scientist - Flow Cytometry





Laboratory, Pfizer Global R&D – Groton Laboratory











Location: Groton, Connecticut



Contact: Dr. John B. Cheng, e-mail: john.b.cheng@pfizer.com, Tel: (860) 441-3351



Role Description



Responsible for independent



initiation and execution of scientific research and/or development strategies



in a biomarker focused flow cytometry laboratory. This senior level scientist



will act as technical scientific expert regarding cellular markers using FACS



and cell imaging technologies to regulated preclinical biomarker and clinical



biomarker translation supporting Pfizer drug candidates. Responsible for



providing flow cytometry data for biomarker discovery and development, support



assay method development and standardization, and contribute toward staff



training and professional development.  Candidate will participate with



departmental teams and research units in a matrix environment. The person



should have proven experience in the delivery of flow and cell imaging-based



biomarkers in animal and clinical studies, and have strong knowledge of



biological systems and cellular function to enable Pfizer discovery and



development objectives.



Responsibilities



- The successful candidate will



have experience developing partnerships in a matrix environment, influencing



project strategies, and leadership in technology development and



implementation.








- Candidate must have experience training and



developing FACS scientists in a team environment. Other responsibilities include



independent planning of laboratory activities, understanding and influencing



therapeutic area biomarker strategies to use biomarkers in scientific



decision-making. 








- Candidate will participate in all phases of FACS



laboratory operations including technology evaluations, the development of



sample preparation, separation and detection methods, data analysis,



interpretation, reporting and follow up discussions with the project teams on



utilizing the data in appropriate decision making.








- Proactively gathers input from colleagues, teams



& management to avoid/address issues at functional level and participates



on cross discipline matrix teams








- Excellent oral/written communication skills







- Demonstrated ability to clearly & concisely



communicate bioanalytical information (including Q&A)








- Understanding of “fit-for-purpose” assay



development and support.  Ability to effectively balance assay rigor



against resource needs and study goals








- Knowledge and understanding of GLP/GCP guidance for



execution of preclinical and clinical studies supporting NCE’s














Qualifications



B.S. (>8 years), M.S. (>6 years), or Ph.D. (>2-4 years) in relevant scientific field with industrial



experience; Experience in development, characterization, and implementation of



quantitative bioanalytical assays (e.g., flow cytometry and cell imaging) using



wet sample preparation methods and instrumentation












Additional qualifications include:







- Experience and knowledge in operation of modern



flow cytometry and cell sorting platforms and associated data/LIMS systems







- Knowledge and application of immunoassay techniques



as applied to flow cytometry techniques







- Knowledge and application of sample preparation



methodologies as applied to flow cytometry techniques







- Good understanding of biochemistry and cellular



biology







- Ability to lead teams, coach and mentor colleagues



and influence in a matrixed environment







- Knowledge and understanding of GLP and GCP



regulations and guidelines







- Good written and oral communication skills







- Ability to act decisively in a matrix environment







- Rapidly seizes accountability and takes independent



initiative







- Ability to deal with project and organizational



change while supporting the organization







- Interested in personal development and professional



growth







- Aware of  self and others