Job Posting Details

Scientist, OMNI-BD Biomarker Flow Cytometry

Posted By: Madison Hartman

Post Date: March 16, 2021
Affiliation: Genentech
Expiration Date: June 16, 2021
Department:
Description:


Join a Team that Lives to Improve Lives


People come to Genentech from across disciplines and across the world to solve our most challenging medical conditions. You’ll find inspiration in our passion for biotechnology, our purpose to positively impact the lives of millions of patients and our dedication to our people. Joining Genentech means being part of a tradition of inquiry that will change the world. It means embracing our failures as much as our successes. It requires a willingness to look beyond the edge of what's possible. And a focus on doing the day-to-day work that makes great science happen. 


 


The following opportunity exists in our South San Francisco, CA headquarters:


 


SCIENTIST, OMNI-BD BIOMARKER FLOW CYTOMETRY


 


Description


We are seeking a highly motivated Scientist to join the OMNI-Biomarker Development group (Flow Cytometry) within the Development Sciences Department to drive our biomarker and drug development efforts across our Genentech pipeline. Our group is responsible for designing and implementing biomarker assays for programs in clinical development at Genentech in immunology, virology, immuno-oncology, hematological oncology, and other new therapeutic areas.  Our group uses relevant biomarkers to evaluate disease heterogeneity, target-engagement, mechanism of action, and disease modification.


 


Who You Are


The successful candidate will join our dynamic team and work to design and implement flow cytometry biomarkers in early and late stage clinical trials of novel therapeutics in our growing pipeline. The desired candidate will have a deep understanding of immunology and cancer biology; demonstrate strong expertise in immunological cell subsets such as effector and regulatory T, B, and/or monocyte subsets; and understand the biomarkers used in flow cytometry to identify these populations in vivo. 


 




  • Attention to detail, good communication, and collaboration skills is essential to excel in this position.




  • Proven cell biology expertise working with a variety of human sample types including whole blood, bone marrow, cell lines and single-cell suspension from tissue samples is expected.




  • Ability to design and execute the development and validation of 8+ color cytometry assays is essential.




  • Experience with and enthusiasm for higher complexity (+18 color, spectral) cytometry platforms is preferred.




  • Experience with advanced analytical and bioinformatics tools such as unsupervised and supervised automated analysis (e.g. ‘R’ scripts, tSNE, FLOWDensity, FLOWSom) for analyzing and visualizing biomarker data is highly valued.




  • Experience with outsourcing flow cytometry assays to contract research organizations (CRO) is highly desirable.




 


Scope of position


This position will report to the Senior Scientific Manager of the Cytometry Biomarker group within the Development Sciences Division of Genentech Research and Early Development. The individual will lead development and execution of cytometry biomarker activities supporting one or more molecules and indications in the non-oncology and oncology disease areas to understand mechanisms of drug action, response and resistance. This position will also be responsible for leading translational efforts between our clinical development and research teams.  Additionally, this role will be responsible for implementing novel pipelines for algorithm-based data analysis of high complexity flow cytometry.  The scope of biomarker activities will span predictive, pharmacodynamic, and prognostic biomarkers as well as response endpoints such as minimal residual disease (MRD).


 


Requirements


Candidates must have a PhD in a field of immunology or a related field with at least 1 to 3 years of post-doctoral or fellowship experience in basic or translational research either in an academic and/or industry setting. The candidate must demonstrate a high level of independence and be able to develop hypotheses and direct analysis plans. Strong writing and communication skills are required, as evidenced by publications, meeting abstracts and/or drug development reports. We are looking for an individual who is passionate about using their understanding of disease biology to make impactful contributions to clinical drug development.  Preferred candidates will have prior experience with immune related diseases, human samples, and a demonstrated ability to function as part of a cross-functional team.


 


Who We Are


Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and


life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.


 


Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society.  We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work. 


 


The next step is yours. To apply today, click on the "Apply online" button.


 


Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.


 


At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.


 


Apply Link: http://bit.ly/3tvQQgZ