Detection of Minimal Residual Lymphoblastic Leukemia
Residual lymphoblastic leukemia following therapy has been shown to be associated with an adverse patient outcome, even when present at 0.01% of total cells.  Read the article by Mikhail Roshal to get some tips on performing successful minimal residual disease testing for lymphoblastic leukemia.

Primary Immunodeficiency Disorders
You’re probably familiar with flow cytometric testing for the acquired immunodeficiency associated with HIV infection, but what do you know about testing for primary immunodeficiency disorders (PID)?  Learn more from interviews Fiona Craig held with the directors of four laboratories known for their expertise in this area.

Autoimmune Lymphoproliferative Syndrome
The hallmark of the primary immunodeficiency disorder autoimmune lymphoproliferative syndrome (ALPS) is expansion of an unique population of T cells that are alpha beta T cell receptor positive and negative for both CD4 and CD8; double negative T cells.  Flow cytometric enumeration of this subset can provide a simple screening test for this PID.  Find out more about ALPS in the article by Michele Paessler.

Chronic Granulomatous Disease
Does your laboratory still perform the Nitroblue tetrazolium (NBT) test for chronic granulomatous disease (CGD)?  Marc Golightly describes the replacement dihydrorhodamine flow cytometric test that can be adopted by most clinical flow cytometry laboratories.

Archive
View previous issues of the ICCS eNewslettter.